A recent study published by the journal Genome Biology was conducted on two groups of parasites, which showed differences in DNA sequences that could be attributed to the composition of diets.
“Organisms construct their DNA using building blocks they get from food,” said the co-author of the study Dr. Steven Kelly. “Our hypothesis was that the composition of this food could alter an organism’s DNA. For example, could a vegetarian panda have predictable genetic differences from a meat-eating polar bear?”
He continued, “To test this hypothesis, we picked simple groups of parasites to use as a model system. These parasites share a common ancestor but have evolved to infect different hosts and eat very different foods.”
According to the research, different levels of nitrogen in a parasite’s diet contributed to changes in its DNA. Specifically, parasites with low-nitrogen, high-sugar diets had DNA sequences that used less nitrogen than parasites with nitrogen-rich, high-protein diets.
The study involved groups of eukaryotic parasites (Kinetoplastida) and bacterial parasites (Mollicutes) that infect different plant or animal hosts.
The results, based on novel mathematical models developed by the researchers, reveal a previously hidden relationship between cellular metabolism and evolution. They provide new insights into how DNA sequences can be influenced by adaptation to different diets.
Furthermore, the team found it is possible to predict the diets of related organisms by analyzing the DNA sequence of their genes.
Study co-author Emily Seward, a doctoral candidate in Oxford’s Department of Plant Sciences, said, “It has been unclear why very closely related organisms can look so different in their genetic makeup. By bringing together two fundamental aspects of biology, metabolism and genetics, we have advanced our understanding of this area.”
Although, Seward admits that there could be many other factors causing the differences in genetic make up, she believes that this study explains a very high percentage of these differences and provides evidence that “we really are what we eat.”
Researchers are now looking at more complex organisms to confirm these findings.
1.Emily A. Seward, Steven Kelly. Dietary nitrogen alters codon bias and genome composition in parasitic microorganisms. Genome Biology, 2016.